Doudna Charpentier

CRISPR Pioneers Doudna and Charpentier Win 2020 Nobel Prize for Chemistry

Predictions over who would win the Nobel Prize for CRISPR have raged for several years. While some speculated that the award might come from the Physiology or Medicine committee, CRISPR-based therapeutics have only just entered the clinic. It will be many years before we see significant medical impact from the technology. That put the spotlight on Chemistry. There was little doubt that, should a Nobel Prize for CRISPR be awarded in Chemistry, Doudna and Charpentier would claim two of the possible three slots.
Generation Bio gene therapy platform

Gene Therapy Startups Extend Biotech’s Legacy

Every new biotech firm hopes to succeed like Genentech, the original biotech startup. Today, several new firms are focused on gene therapy challenges such as vector selection and manufacturing.

Gene Therapy’s Renaissance

Besides addressing lingering safety concerns, gene therapy is exploring applications beyond the correction of single-gene mutations. Possibilities include polygenic and gene-independent approaches.

Viral or Nonviral: Which Is Better for CRISPR-Based Therapies?

Viral vectors offer efficient delivery. (But they’re cramped and potentially pathogenic.) Nonviral vectors privilege safety. (But they’re relatively inefficient.) Fortunately, both are improving.
aeroponics laboratory at Calyxt

Redesigning the Global Food Supply

If you like GMO patchwork, stick with transgenic crop development. But if you want fine tailoring, embrace gene editing. It enhances a plant’s own qualities and has a natural, sustainable look.
Twist Biosciences lab

Synthetic DNA Manufacturer has the “Write Stuff”

In research, the demand for DNA strands often outpaces supply. Researchers needing a few genes have a choice of several providers. But what if researchers need 10,000 genes? “We’re probably the only game in town,” suggests Emily Leproust, PhD, co-founder and CEO of Twist Bioscience. Twist has developed a synthetic DNA manufacturing process that emulates the miniaturization seen in the semiconductor industry.
Adeno-associated virus, illustration

Redefining AAV Manufacturing: The Time Is Now

Oxgene maintains that TESSA—a Tet-enabled self-silencing adenovirus—can change theway that AAV vectors are manufactured, reducing costs, improving quality, and promoting safety.

Precise, Translational Delivery for CNS Gene Therapies

Refining the delivery method so that the desired gene reaches the right part of the brain in the right amounts can be especially challenging in larger animals that are the key to obtaining data that translates to the clinic. Choosing to work with a seasoned research partner like Charles River Laboratories provides access to decades of experience at every step of the process.

Call for a Citizens’ Assembly to Help Govern Genome Editing

In response to calls for more inclusive participation in the governance of genome editing technologies and their applications, a Policy Forum has proposed the creation of a global citizens’ assembly. Composed of a minimum of 100 lay citizens from around the world and informed by experts, the assembly would explore and deliberate the implications of genome editing technologies and regulatory principles.
illustration DNA wire frame Futuristic digital  design,Abstract background for Business Science and technology

Data Management in the DNA of New Gene Therapy Plant

Catalent’s third gene therapy facility at Harmans, MD, will use a sophisticated infrastructure that is able to gather, manage, and analyze data across all operations.

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