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SARS-CoV-2 Genomic Analysis Traces U.K. Transmission Lineages

A study of over 50,000 SARS-CoV-2 genomes has produced an analysis of the genetic lineage structure and importation dynamics of the first wave of the COVID-19 epidemic in the U.K. The results show that it’s possible to use genomic tracking to trace individual virus transmission lineages accurately through time and space.

Prostate Cancer Risk Potentially Decreased by Following the Mediterranean Diet

Researchers from the University of Texas MD Anderson Cancer Center found that men with localized prostate cancer who follow the key principles of a Mediterranean-style diet fared better over the course of their disease.

Trojan Horse Antidotes Designed to Neutralize Lethal Botulinum Toxin

Botulinum neurotoxins (BoNTs) are classified by the United States Centers for Disease Control and Prevention (CDC) as one of the most dangerous bioterrorism agents. BoNTs infiltrate into motor neurons, block neurotransmitter release, and stop essential functions such as breathing. Two independent studies have used nontoxic derivatives of BoNT to deliver therapeutic antibodies that bind and neutralize these toxins within neurons.

Accelerating Vaccine Development through Use of Blood-Free Components

This GEN webinar, sponsored by Invitria, will discuss the real contamination risks described in a recent study and how companies are rising to this challenge through a better selection of components and excipients.

Cancer Cells Can Hibernate En Masse to Survive Chemotherapy

Tapping into an ancient evolutionary survival mechanism, cancer cells can enter a sluggish, slow-dividing state to survive the harsh environment created by chemotherapy or other targeted agents. This mechanism, called diapause, appears to be accessible to all cancer cells, not just a subset.

Proper Antibody Design Keeps Specificity in Mind

In this eBook, sponsored by Origene, you will read about the fascinatingways bioengineering has changed how antibodymolecules are applied to research and the clinicalworld. Despite all the changes, specificity remainsthe core value determinant of an antibody, albeitnaturally or recombinantly made.

Gut Inflammation Triggered by E-Cigarettes

UCSD scientist found that the chronic use of nicotine-free e-cigarettes led to a "leaky gut," in which microbes and other molecules seep out of the intestines, resulting in chronic inflammation. Such inflammation can contribute to a variety of diseases and conditions, including inflammatory bowel disease, dementia, certain cancers, atherosclerosis, liver fibrosis, diabetes, and arthritis.

Cell Surface Protein Array Modulates Cell Responses

When antibody drugs bind to their target receptors, they become internalized and degraded. Protein engineers sought a solution to this problem by designing proteins that assemble into large, flat patches. Their data show that these protein arrays could latch onto cells, activate surface receptors, and resist being absorbed by the cell for hours or even days.

Ginger Compound Demonstrates Protective Role against Autoimmune Disorders in Mice

Studies by a team at the University of Michigan found that 6-gingerol, the main bioactive compound in ginger root, has therapeutic effects against the autoimmune diseases, lupus and antiphospholipid syndrome (APS), in mice, by countering the release of neutrophil extracellular traps (NETs), and reducing autoantibody production. The researchers say their findings point to the potential use of ginger as a supplement to help prevent autoimmune disorders in people at risk.

Exploring the Origins of Antibiotic Resistance Genes

Scientists in Gothenburg, Sweden, reported they have traced back the evolutionary history of antibiotic resistance genes, by comparing bacterial genomes. In almost all cases where an origin could be determined, the gene started to spread from bacteria that, themselves, can cause disease.

Novel Anti-fibrotic Therapy for Glaucoma

A low molecular weight dextran-sulphate could play a key role in treating open angle glaucoma, a neurodegenerative disease that affects over 70 million people worldwide and causes irreversible blindness.

Marine Natural Products Identified with Potential to Treat Lethal RNA Viruses

Systematic collection and analysis of natural marine compounds and the review of life histories and genomics of three families of RNA viruses reveal compounds that could disrupt viral spread and offers hope for developing new viral therapeutics.

Monoclonal Antibodies: Developers Explore New Territories

The antibody world is broadening thanks to the introduction of antibody mimetics, novel antibody formats, conformational and signaling applications, and more.

Uncharted Territory: Top Challenges Facing Gene Therapy Development

Scientists from three different institutions share their perspectives on the future of gene therapy.

Engineering Biology—Accelerating Transition

New solutions in biomedical research are propelling the field by leaps and bounds ahead of what was accomplished in decades past. Biotechnology and particularly genome engineering are driving new paradigms for healthcare access and contributing to a new healthcare ecosystem.

Bioprocessing in a Post-COVID-19 World

COVID-19 has compressed bioprocessing timelines, leaving no room for uncertainty in the characterization of raw materials and contaminants.

Sustainability and the Synthetic Biology Revolution

Synthetic biology has become a powerful tool to advance science, making processes more efficient, enabling completely new approaches to biology, and helping scientists find the right answers, faster. These capabilities are having a ripple effect. They help researchers pursue avenues that had not been economically feasible or, in some cases, scientifically possible. Twist Bioscience anticipates that DNA writing technology will help advance precision medicine, curb pollution, conserve energy, and store data more securely.

Envisioning Future Trends in Regenerative Medicine

Regenerative medicine is poised to improve and impact healthcare and technology trends in 2021 and beyond.

Customized Glycoengineering in Plant-Based Expression Systems

iBio describes its FastPharming system, which promises to expedite process development.

Supercharge Antibody Discovery Workflows with High-Throughput SPR

By screening and characterizing antibodies at the same time, HT-SPR can help researchers identify the best drug candidates from a vast library of antibodies in just hours or days. Deducing which epitope each antibody binds, how strongly it binds, and its mechanism of action make the new techniques mandatory for any lab that wants to keep pace.

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