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Synthetic Biology and the Future of Food, Fashion and Pharma

The synthetic biology revolution is here! In this presentation, sponsored by Twist Bioscience, we are excited to bring together leaders in the field. Our April episode of GEN Live, our guests discuss where the field is now and the exciting advances in store for the future.

Bacteriophage to the Future: Insights from the 3rd Bacteriophage Therapy Summit

Challenges facing phage therapy range from a developing regulatory landscape and the design of clinical trials to the up-scaling of manufacturing processes. With lots of good science, practicality considerations, and clinical strategies along with funding concerns, the 3rd Bacteriophage Therapy Summit provided a great opportunity to discuss the current state of phage therapy and the pathway to regulatory approval.

Scientific Challenges and Solutions for Cultured Meat Manufacturing

Several key challenges remain in producing cultured meat including access to proprietary cell lines, high raw material cost, animal-source nutrients, and limited manufacturing scale. Despite this, immense progress has been made over the last decade.

You Can See Manhattan from Your Lab: $3B “Cove” Campus Announced in Jersey City

To fill the project’s planned lab space, The Cove looks to draw upon the region’s numerous life-sci employers, New Jersey’s sizeable life-sci labor force, and Jersey City’s urban dynamic in a state where most life sciences space is within suburban or exurban lab-office campuses built a generation ago.

Studies in Mice Help to Explain Why Redheads Have Different Pain Thresholds

Studies by an MGH-led research team have offered up new insights into why people with red hair exhibit altered sensitivity to certain kinds of pain. Their work in red-haired mice with loss of melanocortin 1 receptor function could help point to new ways to manipulate the body's natural mechanisms for controlling pain perception, for example, by designing drugs that inhibit pain-sensing receptors.

Baltic Amber Gives Rise to Paleopharmaceuticals

Each year in the U.S., at least 2.8 million people get antibiotic-resistant infections, leading to 35,000 deaths, according to the U.S. CDC. Ancient amber (fossilized tree resin) have been used by humans in Baltic countries for medicinal purposes for centuries. Now, researchers from the University of Minnesota have pinpointed compounds that help explain Baltic amber's therapeutic effects and that could lead to new medicines to combat antibiotic-resistant infections.

New RNA-Sequencing Method Opens a Pandora’s Box of Opportunity

RNA sequencing provides researchers with visibility into previously undetected changes occurring in disease states, in response to therapeutics, under different environmental conditions, and across a broad range of other study designs. A new RNA sequencing method called “Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing” or PANDORA-seq developed by scientists from the University of California, Riverside, can help discover numerous modified small RNAs that were previously undetectable.

CARB-X Funds Optimization, Scaleup, and Production of New Gonorrhea Vaccine

The vaccine aims to curb the global spread of gonorrhea and strains of super gonorrhea antibiotic-resistant bacteria.

Bioprocessing Psilocybin for Mental Health

Novel production technique reportedly does not require a lot of expensive reagents or multiple purification steps and produces much higher yields—about three times higher than other methods.

Better Sensors Critical Key for Faster, Cheaper Process Development

Biopharma needs better sensors to realize the full benefits of data driven manufacturing, according to the director of the soon to be expanded Jefferson Institute for Bioprocessing.

The mRNA Therapeutics Boom

In this article Thermo Fisher Scientific provides information on how to simplify workflows and maximize the efficiency of the mRNA purification process with POROS™ Oligo (dT)25 affinity resin.

Delivering Key Omic Insights for Curative Medicine

In this eBook see how IsoPlexis’ multifaceted functional proteomics platform enables single-cell secreted proteomics, low-volume highly multiplexed proteomics from serum, single-cell phosphoprotein analysis, and single-cell metabolomic analysis all on one integrated, benchtop system, making functional proteomics accessible to virtually every lab worldwide.

CRISPR Single-Cell Screening Drives Biological Discovery

In this GEN webinar, sponsored by Horizon Discovery, we will present data showing how a new CRISPRsc screening platform from Horizon offers a streamlined approach to elucidating valuable and intriguing biological information critical to resolving complex biological questions.

Piramal Pharma Agrees to Acquire Hemmo Pharmaceuticals

Piramal’s integrated drug substance and drug product offering will now include peptides.

Sanofi Inks Agreement to Build Influenza Vaccine Manufacturing Facility in Canada

Canadian officials say the investment demonstrates the government’s commitment to grow domestic manufacturing capacity and to prepare for future pandemics.

Epizyme Charts Five-Year Clinical Vision, Seeing Silver Linings Amid Tazverik Clouds

Epizyme recently detailed its development strategy and pipeline priorities over the next five years during a “Strategic Vision Call.” Those priorities include launching two signal-finding “basket” studies in the second half of 2021 to evaluate tazemetostat safety and efficacy across multiple new types of blood and solid tumors; and advancing to the clinic its SETD2 inhibitor program.

Mutation-Specific RNA Therapy Can Improve Vision with Lasting Effects

A Penn Medicine patient with a genetic form of childhood blindness gained vision, which lasted more than a year, after receiving a single injection of an experimental RNA therapy into the eye. Results from the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania trial showed that the treatment led to marked changes at the fovea, the most important locus of human central vision. The treatment was designed for patients diagnosed with Leber congenital amaurosis (LCA), an eye disorder that primarily affects the retina, who have a CEP290 mutation.

Molecular Switch Identified That Flips from Self-Renewal to Specialization in the Making of a Kidney

Scientists decipher the mechanisms by which beta-catenin, a co-activator of the developmental molecular pathway called Wnt signaling, regulates both self-renewal and specialization during the developmental program that leads to the formation of a kidney. The study reports raised levels of the co-activator flips the switch from self-renewal to specialization by replacing transcription factors at primed gene targets.

Biomarker Discovery Could Aid Development of Senolytic Drugs Against Age-Related Disorders

Buck Institute researchers discovered a novel oxylipin biomarker, detectable in blood and urine, which could form the basis of a noninvasive test to measure and track the performance of senolytics, a class of drugs that selectively eliminate senescent cells. They hope a noninvasive test for dihomo-15d-PGJ2 could be used as a companion diagnostic.

Scientists Create Living Machines That Move, Heal, Remember and Work in Groups

Scientists at Tufts University and the University of Vermont have created tiny living machines from frog stem cells. This provides a cellular platform that can be used to study self-assembly, swarm behavior, and synthetic bioengineering, and offers versatile, soft-body living machines for practical applications in biomedicine and the environment.

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