The synthetic biology revolution is here! In this presentation, sponsored by Twist Bioscience, we are excited to bring together leaders in the field. Our April episode of GEN Live, our guests discuss where the field is now and the exciting advances in store for the future.
Challenges facing phage therapy range from a developing regulatory landscape and the design of clinical trials to the up-scaling of manufacturing processes. With lots of good science, practicality considerations, and clinical strategies along with funding concerns, the 3rd Bacteriophage Therapy Summit provided a great opportunity to discuss the current state of phage therapy and the pathway to regulatory approval.
Several key challenges remain in producing cultured meat including access to proprietary cell lines, high raw material cost, animal-source nutrients, and limited manufacturing scale. Despite this, immense progress has been made over the last decade.
To fill the project’s planned lab space, The Cove looks to draw upon the region’s numerous life-sci employers, New Jersey’s sizeable life-sci labor force, and Jersey City’s urban dynamic in a state where most life sciences space is within suburban or exurban lab-office campuses built a generation ago.
Studies by an MGH-led research team have offered up new insights into why people with red hair exhibit altered sensitivity to certain kinds of pain. Their work in red-haired mice with loss of melanocortin 1 receptor function could help point to new ways to manipulate the body's natural mechanisms for controlling pain perception, for example, by designing drugs that inhibit pain-sensing receptors.
Each year in the U.S., at least 2.8 million people get antibiotic-resistant infections, leading to 35,000 deaths, according to the U.S. CDC. Ancient amber (fossilized tree resin) have been used by humans in Baltic countries for medicinal purposes for centuries. Now, researchers from the University of Minnesota have pinpointed compounds that help explain Baltic amber's therapeutic effects and that could lead to new medicines to combat antibiotic-resistant infections.
RNA sequencing provides researchers with visibility into previously undetected changes occurring in disease states, in response to therapeutics, under different environmental conditions, and across a broad range of other study designs. A new RNA sequencing method called “Panoramic RNA Display by Overcoming RNA Modification Aborted Sequencing” or PANDORA-seq developed by scientists from the University of California, Riverside, can help discover numerous modified small RNAs that were previously undetectable.
The vaccine aims to curb the global spread of gonorrhea and strains of super gonorrhea antibiotic-resistant bacteria.
Biopharma needs better sensors to realize the full benefits of data driven manufacturing, according to the director of the soon to be expanded Jefferson Institute for Bioprocessing.
In this eBook see how IsoPlexis’ multifaceted functional proteomics platform enables single-cell secreted proteomics, low-volume highly multiplexed proteomics from serum, single-cell phosphoprotein analysis, and single-cell metabolomic analysis all on one integrated, benchtop system, making functional proteomics accessible to virtually every lab worldwide.
In this GEN webinar, sponsored by Horizon Discovery, we will present data showing how a new CRISPRsc screening platform from Horizon offers a streamlined approach to elucidating valuable and intriguing biological information critical to resolving complex biological questions.
Piramal’s integrated drug substance and drug product offering will now include peptides.
Canadian officials say the investment demonstrates the government’s commitment to grow domestic manufacturing capacity and to prepare for future pandemics.
Epizyme recently detailed its development strategy and pipeline priorities over the next five years during a “Strategic Vision Call.” Those priorities include launching two signal-finding “basket” studies in the second half of 2021 to evaluate tazemetostat safety and efficacy across multiple new types of blood and solid tumors; and advancing to the clinic its SETD2 inhibitor program.
A Penn Medicine patient with a genetic form of childhood blindness gained vision, which lasted more than a year, after receiving a single injection of an experimental RNA therapy into the eye. Results from the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania trial showed that the treatment led to marked changes at the fovea, the most important locus of human central vision. The treatment was designed for patients diagnosed with Leber congenital amaurosis (LCA), an eye disorder that primarily affects the retina, who have a CEP290 mutation.
Molecular Switch Identified That Flips from Self-Renewal to Specialization in the Making of a Kidney
Scientists decipher the mechanisms by which beta-catenin, a co-activator of the developmental molecular pathway called Wnt signaling, regulates both self-renewal and specialization during the developmental program that leads to the formation of a kidney. The study reports raised levels of the co-activator flips the switch from self-renewal to specialization by replacing transcription factors at primed gene targets.
Buck Institute researchers discovered a novel oxylipin biomarker, detectable in blood and urine, which could form the basis of a noninvasive test to measure and track the performance of senolytics, a class of drugs that selectively eliminate senescent cells. They hope a noninvasive test for dihomo-15d-PGJ2 could be used as a companion diagnostic.
Scientists at Tufts University and the University of Vermont have created tiny living machines from frog stem cells. This provides a cellular platform that can be used to study self-assembly, swarm behavior, and synthetic bioengineering, and offers versatile, soft-body living machines for practical applications in biomedicine and the environment.